Cagrilintide

Fa'amatalaga Puupuu:

O le Cagrilintide o se vailaʻau faʻapipiʻi, o le amylin receptor agonist umi ua atiaʻe mo le togafitia o le tino puta ma faʻafitauli o le tino. E ala i le fa'ata'ita'iina o le hormone amylin, e fesoasoani e fa'atonutonu le mana'o, fa'agesegese le gaogao o le manava, ma fa'amalieina ai le fa'amalieina. O la matou Cagrilintide API maualuga-mama e gaosia e ala i vailaʻau faʻapipiʻi ma faʻafetaui tulaga faʻataʻitaʻiga o vailaʻau, e talafeagai mo le faʻaogaina i faʻasologa o le mamafa o le mamafa.

Auina imeli ia matou

Fa'amatalaga Oloa

Faailoga o oloa

Cagrilintide API

Cagrilintideose mea e umi ona galue, fa'a kemikoloamylin receptor agonist, atiina ae o se togafitiga fou mooona ma faaletonu metabolic e fesootai i le mamafa. Ua mamanuina e fa'atusa ai a'afiaga oamylin tagata, o se hormone na fa'aulu fa'atasi ma le inisalini e le pancreatic β-cells, lea e iai sona sao taua i le fa'atonutonuina o mea'ai, ga'o ga'o, ma le fa'amalieina.

Cagrilintide o loʻo atinaʻe e pei o setogafitiga tui e tasi-vaiaso, ofoina atu se fofo sili ona folafola mopulega mamafa masani, aemaise pe a faʻaaogaina i totonufaʻatasi ma GLP-1 agonists talitalipei o leSemaglutide.

Mechanism of Action

O le Cagrilintide e faʻaaogaina ona aʻafiaga e ala i le fusifusia ma faʻagaoioiae tali atu ai le amylin, e tau atu i:

Taofi le fia'ai
Fa'atuai le fa'amama o le manava, lea e faaumiumi ai le lagona o le tumu
Faʻaitiitia le faʻaogaina o le kalori ma faʻateleina le faʻamalieina

O lenei tulafono faatonutonu tele o taumafa taumafa ua avea ai ma sui lelei mo le puleainaputa'a ma fa'alavelave fa'aletonu ile cardiometabolic.

Su'esu'ega ma Fa'amatalaga Fa'afoma'i

Cagrilintide ua faʻaalia taunuuga manuia i le tele o faʻataʻitaʻiga, e aofia aiVaega 2 suʻesuʻega na faia e Novo Nordisk:

Pe a faʻaaogainatoatasi, Cagrilintide e tau atu ipa'u mamafa fa'alagolago fua, e oo atu i10.8% fa'aitiitia le mamafa o le tinoi luga ole 26 vaiaso i tagata lapopoa.
O afeafaʻatasi ma Semaglutide, o le aafiaga o le pa'u o le mamafa e matua fa'aleleia—ausiafa'aitiitiga sili atu le mamafa o le tino nai lo na'o so'o se sui.
Ua faaaliatalia leleimase talaaga saogalemu tumau, fa'atasi ai ma le tele o fa'alavelave fa'aletonu o fa'ailoga vaivai ole manava.

O lenei faiga tu'ufa'atasi o se vaega taua o lelaina paipa fualaau faasaina anti-obesity tupulaga e sosoo ai, fa'atatau i le tele o auala fa'amalieina (amylin + GLP-1).

API Tulaga lelei ma Gaosiga

O tatouCagrilintide API:

E gaosia e ala i lumafa'atasiga peptide fa'amautu (SPPS)faʻatasi ai ma le mama maualuga ma le mautu o vailaʻau
Ua mamanuina moatina'e fa'asusu fa'a tui
Feiloai faavaomalotulaga tau vailaau (ICH, GMP, FDA)
E maua i totonupailate i le gaosiga fa'apisinisi, talafeagai mo falemaʻi ma faʻaoga faʻapisinisi

Togafitiga Fomai

Cagrilintide o loʻo faʻatusalia afaiga foui le puleaina o le mamafa i tua atu o le GLP-1 monotherapy. O lona fa'asologa fa'atasi o gaioiga e fa'atatau mo: