Daptomycin 103060-53-3 mo faʻamaʻi pipisi
Fa'amatalaga Oloa
| Igoa | Daptomycin |
| Numera CAS | 103060-53-3 |
| fua mole | C72H101N17O26 |
| mamafa mole | 1620.67 |
| EINECS Numera | 600-389-2 |
| Liu liusuavai | 202-204°C |
| Fa'apuna | 2078.2±65.0 °C (Va'ai) |
| Malosi | 1.45±0.1 g/cm3(Va'ai) |
| Fa'ailoga moli | 87 ℃ |
| Tulaga teuina | Faamaufa'ailoga i le mago, Teu i totonu o le pusaaisa, i lalo ole -20°C |
| Solubility | Methanol: soluble5mg/mL |
| Acidity coefficient | (pKa) 4.00±0.10 (Vailoaina) |
| Fomu | pauta |
| Lanu | e leai se lanu i le samasama vaivai |
Synonyms
N-[N-(1-Oxodecyl)-L-Trp-D-Asn-L-Asp-]-cyclo[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-4-)L-Aminophenyl ;N-[N-Decanoyl-L-Trp-D-Asn-L-Asp-]-cyclo[Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R) -3-methyl-L-Glu-]-3-(2-La-aminobenzoyl)-]-O; ecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R) -3-methyl-L-α- glutamyl-α,2-diamino-γ-oxo-benzenebutanoicacid(13-4)lactone;DAPTOMYCINE;Dapcin;Daptomycin,>=99%;DaptomycinReadyMadeSolution;Daptomycin(LY146032)
Fa'amatalaga
O le antibiotic daptomycin o se cyclic lipopeptide antibiotic ma se fausaga fou na maua mai le susu faʻafefeteina o Streptomyces (S. reseosporus), lea e taofia ai le biosynthesis o le peptidoglycan puipui siama siama e ala i le faʻalavelaveina o le felauaiga o amino acids i totonu o le membrane cell. O le suia o meatotino o le cytoplasmic membrane e mafai ona faʻalavelaveina le gaioiga o le membrane siama i le tele o auala ma vave faʻaumatia siama Gram-positive. I le faaopoopo atu i lona gafatia e galue i luga o le tele o siama Gram-positive e talafeagai ile falemaʻi, e sili atu le taua o le daptomycin mo aʻafiaga tuʻufua na faʻaalia ai le tetee i le methicillin, vancomycin, ma le linezolid in vitro. E malosi lona gaioiga, ma o lenei meatotino e iai sona aafiaga taua tele mo tagata mamaʻi mamaʻi. O le niumonia Eosinophilic ose fa'ama'i e seasea ma ogaoga ma fa'ailoga e aofia ai le fiva, tale, le manava, ma le faigata ona manava.
Aafiaga antibacterial
O le Daptomycin e lelei le gaioiga fa'ama'i e fa'asaga i siama fa'ama'i fa'ama'i eseese, e pei o le MIC=0.06-0.5 μg/ml mo Staphylococcus aureus (MRSA) e tetee i le methicillin (MRSA), ma le Staphylococcus aureus e tetee i le methicillin (MRSA). MIC=0.0625～1μg/ml mo siama, MIC=0.12～0.5μg/ml mo Staphylococcus epidermidis e tetee i oxacillin, MIC=2.5μg/ml mo enterococcus e matua tetee atu i vailaau aminoglycoside, MIC=2.5μg/ml mo Gmr. 0.5～1μg/ml, ma ole MIC ole Enterococcus e tetee ile glycopeptide antibiotic e 1~2μg/ml.
