Daptomycin 1030602-53-3 mo faʻamaʻi pipisi
Faamatalaga auiliiliga
| Igoa | Daptomycin |
| Telefoni numera | 103060-53-3 |
| Molecular forlala | C72H101N17O26 |
| Molecular mamafa | 1620.67 |
| Numera numera | 600-389-2 |
| Liusuavai manatu | 202-204 ° C |
| Pulu | 2078 ± 65.0 ° C (valoia) |
| Tulaga | 1.45 ± 0.1 G / CM3 (valoia) |
| Vlish Point | 87 ℃ |
| Taaloga aiaiga | Faʻamaufaʻailoga i le matutu, teuina i totonu o le 'aisa, lalo -20 ° C |
| Sofusi | Methanol: Mamalute5mg / ml |
| Actidity | (PKA) 4.00 ± 0.10 (valoia) |
| Fomu | powder |
| Lanu | lanu e samasama samasama |
Uiga tutusa
N- [N- (1-Oxodocyll) -l-trp-d-asn-l-asp -] - o le l-b-getyl-dLo-l-getyl ; __ [n-decanoyl-l-trp-d-ann-l-asp -] - O le chrac [Type-l-aprey Ecyl) -l-trandptoptophyl-d-asparagyl-l-asparyl-l-winyll Glutumyl-α, 2-Damino-γ-Olko-Benzenebunicaccid (13-4) LactomyCecin,> Daptomycin (Ly146032)
Faʻamatalaga
O le antibiotic daptomycin o se cyclic lipopeptit bibibictic ma se fausaga fou e aveese mai le palu o le wactathoglycan) O le suia o meatotino a le cytoplasmic membrane e mafai ona faʻalavelaveina ai le gaʻo o le siama i le tele o auala ma vave fasiotia le kalama-mama. I le faʻaopopo atu i lona tomai e galue ai i le sili atu le aoga o kalama-lelei, Daptoomycain e sili atu ona taua mo soʻoga, valecolin, ma laina laina i le vitro. E i ai lona gaioiga lelei, ma o lenei meatotino e sili ai ona afaina ai fale faʻaletupe mo tagata gasegase faʻaleagaina tagata maʻi. Eononophilc Pneumonia o se seasea ma matua ogaoga faʻamaʻi ma faʻailoga e aofia ai fiva, tale, le manava o le manava, ma faigata ona manava.
Antibactal aafiaga
Daptomycin ei ai le lelei bacceiostatic gaioiga faasaga i eseese antibiotic-solia siama, pei o mictarsia, pei o le μπαous μso (MrsAs Aareus (MRSA). Micro = 0.0625 ~ 1μg / ml mo siama, micro = 0.12 ~ 0.5μcs, Mid = xim mo le GMROCOM- 0.5 ~ 1μg / ml, ma le Mid of Tretrococcus tetee i Glycopeptity Antibiotics o le 1 ~ 2 2and / ml.
