Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH

Fmoc-L-Lys[Ste(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH

Talosaga su'esu'e:
O lenei fa'aputu o se fa'aliliuga o le lysine ua fa'aogaina i le peptide synthesis, aemaise lava mo le fausiaina o peptide conjugates taula'i po'o multifunctional. O le vaega Fmoc e fa'atagaina le fa'asologa fa'asolosolo e ala ile Fmoc solid-phase peptide synthesis (SPPS). O le filifili o le itu e suia i le stearic acid derivative (Ste), γ-glutamic acid (γ-Glu), ma le lua AEEA (aminoethoxyethoxyacetate) soʻotaga, lea e maua ai le hydrophobicity, meatotino tau, ma fetuutuunai avanoa. E masani ona suʻesuʻeina mo lana matafaioi i le tuʻuina atu o vailaʻau, e aofia ai le antibody-drug conjugates (ADCs) ma le peptides e tuʻuina i totonu.

Galuega:
Fmoc-L-Lys[Ste(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH e galue o se poloka fale mo le atinaʻeina o peptides lipidated filifili umi poʻo vailaʻau faʻafesoʻotaʻi lavelave. O le stearic acid e faʻaleleia ai le vavalalata o le membrane, γ-Glu faʻaleleia le mautu ma le enzymatic teteʻe, ma AEEA fesoʻotaʻiga e maua ai le solubility ma le faʻatulagaina o fetuutuunaiga. Faʻatasi, o nei foliga e faʻaogaina ai le tuʻufaʻatasiga taua i le fuafuaina o peptides mo le faʻaleleia atili o le bioavailability, faʻasaʻo faʻatonutonu, ma faʻatatau i le tuʻuina atu o talosaga.