Fmoc-Thr(tBu)-Phe-OH

Fmoc-Thr(tBu)-Phe-OH

Talosaga su'esu'e:
Fmoc-Thr(tBu)-Phe-OH o se poloka fale dipeptide e masani ona faʻaaogaina i le faʻaogaina o le peptide solid-phase (SPPS). O le vaega Fmoc (9-fluorenylmethyloxycarbonyl) e puipuia le N-terminus, ae o le tBu (tert-butyl) vaega e puipuia le filifili hydroxyl o le threonine. O lenei dipeptide puipuia o loʻo suʻesuʻeina mo lana matafaioi i le faʻafaigofieina o le peptide elongation lelei, faʻaitiitia le racemization, ma le faʻataʻitaʻiina o faʻasologa faʻasologa faʻasologa i le fausaga o porotini ma suʻesuʻega fegalegaleaiga.

Galuega:
O le Fmoc-Thr(tBu)-Phe-OH o loʻo avea o se mea muamua mo le faʻapipiʻiina o peptides e aofia ai toega o le threonine ma le phenylalanine, lea e taua mo le fausia o fusi hydrogen ma fegalegaleaiga hydrophobic. O le filifili itu threonine e saofagā ai le polarity ma nofoaga phosphorylation ono mafai, ae faaopoopo le phenylalanine uiga manogi ma le mautu o le fausaga. O lenei tuufaatasiga e aoga i le mamanuina o peptides mo suʻesuʻega o meaola, suʻesuʻega o loʻo fusifusia, ma suʻesuʻega o fualaau faasaina.