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Igoa atoa:Vaega Puipuia o le Tino-157, apentadecapeptide (15-amino acid peptide)na mua'i vavae'eseina mai le sua o le manava o le tagata.
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Fa'asologa ole amino acid:Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, mamafa mole ≈ 1419.55 Da.
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Pe a faatusatusa i le tele o isi peptides, BPC-157 e matua mautu i le vai ma le sua oona, lea e mafai ai ona faʻaogaina le tautala poʻo le gastric.
Faiga Fa'atino
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Angiogenesis / Fa'aola Fa'aola
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Fa'atonuVEGFR-2fa'aaliga, fa'alauiloa le fa'atupuina o va'a toto fou.
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Fa'agaoioia leSrc–Caveolin-1–eNOS auala, e taʻitaʻia ai le faʻamaʻiina o le nitric oxide (NO), vasodilation, ma faʻaleleia galuega faʻapitoa.
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Anti-inflammatory & Antioxidant
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Fa'alaloina cytokine pro-inflammatory pei oleIL-6maTNF-α.
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Faʻaitiitia le gaosiga o meaola okesene (ROS), puipuia sela mai faʻamaʻi faʻamaʻi.
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Fa'alelei Tisu
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Faʻaleleia le faʻaleleia ma le faʻaleleia o galuega i tendon, ligament, ma maso manua faʻataʻitaʻiga.
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Tuuina atu le neuroprotection i faʻataʻitaʻiga o manuʻa o le neura tutotonu (faʻalavelave faʻalavelave, cerebral ischemia-reperfusion), faʻaitiitia le oti o le neuronal ma faʻaleleia le toe faʻaleleia o le afi / lagona.
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Fa'atonuga o le Vascular Tone
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Ex vivo vascular suʻesuʻega o loʻo faʻaalia ai le BPC-157 e faʻaosofia ai le vasorelaxation, faʻalagolago i le endothelium ma le NO auala.
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Manu & In Vitro Fa'atusa Fa'amatalaga
| Ituaiga Fa'ata'ita'i | Fa'ata'ita'iga / Fa'asagaga | Fuafuaga / Pulega | Pulea | I'uga Autu | Fa'amatalaga Fa'atusatusa |
|---|---|---|---|---|---|
| Vasodilation (rat aorta, ex vivo) | Phenylephrine-muamua mama aortic | BPC-157 e oʻo atu i le100 μg/ml | Leai BPC-157 | Vasorelaxation ~37.6 ± 5.7% | Fa'aitiitia i10.0 ± 5.1% / 12.3 ± 2.3%fa'atasi ai ma le NOS inhibitor (L-NAME) po'o le NO scavenger (Hb) |
| Su'esu'ega sela endothelial (HUVEC) | aganuu HUVEC | 1 μg/ml | Pulea le togafitia | ↑ LEAI gaosiga (1.35-papa); ↑ femalagaiga o sela | Ua soloia le femalagaiga ma le Hb |
| Fa'ata'ita'i lala (iole) | Ischemia o lima lima | 10 μg/kg/aso (ip) | Leai se togafiti | Faʻateleina le toe faʻaleleia o le toto, ↑ angiogenesis | Togafitiga > Pulea |
| Fa'a'omiga o le tui (iole) | Sacrococcygeal fa'ama'i fa'alavelave | tui tasi ip 10 min ina ua uma le manu'a | Vaega e le togafitia | Taua tele neura ma toe faʻaleleia | O le vaega pulea na tumau pea le ma'i |
| Fa'ata'ita'iga Hepatotoxicity (CCl₄ / ava malosi) | Manu'a o le ate ona o vaila'au | 1 µg po'o le 10 ng/kg (ip / tautala) | Le togafitia | ↓ AST/ALT, faaitiitia necrosis | O le vaega fa'atonutonu na fa'aalia manu'a tuga o le ate |
| Su'esu'ega oona | isumu, lapiti, maile | Tele tui / auala | Pulea placebo | Leai se oona tele, leai se LD₅₀ na matauina | E talia lelei e tusa lava pe maualuga fua |
Suesuega a Tagata
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Fa'asologa o mataupu: Intra-articular tui ole BPC-157 i le 12 tagata gasegase ma le tiga o tulivae → 11 na lipotia mai le tele o tiga tiga. Tapulaʻa: leai se vaega faʻatonutonu, leai se tauaso, faʻamoemoega.
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Su'ega fa'afoma'i: Sa faia se suʻesuʻega o le saogalemu ma le pharmacokinetic Phase I (NCT02637284) i 42 volenitia soifua maloloina, ae e leʻi faʻasalalauina iʻuga.
I le taimi nei,leai ni fa'ata'ita'iga fa'atonutonu fa'ata'ita'i maualuga (RCTs)o lo'o avanoa e fa'amaonia ai le aoga ma le saogalemu.
Saogalemu & Avanoa Tulaga lamatia
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Angiogenesis: E aoga mo le fa'amaloloina, ae mafai ona fa'aosoina le fa'atupuina o le tumo, fa'avaveina le tuputupu a'e po'o le metastasis i gasegase o le kanesa.
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Fuafuaga & Pulega: E aoga i manu i tui maualalo (ng–µg/kg), ae o le fua o le tagata ma le auala e sili ona lelei e tumau pea le le fa'amalamalamaina.
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Fa'aoga umi: Leai se fa'amatalaga atoatoa o mea oona mo se taimi umi; o le tele o su'esu'ega e pupuu.
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Tulaga fa'atulafonoina: E le faʻatagaina e avea o se vailaʻau i le tele o atunuu; fa'avasegaina amea fa'asainae le WADA (World Anti-Doping Agency).
Malamalamaga Faatusatusa & Tapulaa
| Faatusatusaga | Malosiaga | Tapulaa |
|---|---|---|
| Manu vs Tagata | O a'afiaga lelei faifaipea i manu (tendon, nerve, lipea o le ate, angiogenesis) | O faʻamaoniga a tagata e laʻititi, le pulea, ma leai se tulitatao umi |
| Fuafuaga o fua | E aoga i tui maualalo i manu (ng–µg/kg; µg/ml in vitro) | Saogalemu/lelei tui ole tagata e le iloa |
| Amata o gaioiga | Fa'ata'ita'iga vave pe a mae'a manu'a (fa'ata'ita'iga, 10 min ina ua mae'a le manu'a) e maua ai le malosi malosi | E le o manino le tulaga fa'apitoa ole taimi fa'apea |
| Oona | Leai se fua fa'amata'u po'o ni a'afiaga tuga e matauina i le tele o ituaiga manu | Oona mo taimi umi, carcinogenicity, ma le saogalemu o le fanautama e tumau pea le le tofotofoina |
Fa'ai'uga
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BPC-157 o loʻo faʻaalia ai le malosi faʻafouina ma le puipuiga i faʻataʻitaʻiga manu ma sela: angiogenesis, anti-flammation, toe faʻaleleia o le tino, neuroprotection, ma le hepatoprotection.
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E matuā tapulaa lava faamaoniga a tagata, e leai ni fa'amatalaga fa'ata'ita'iga fa'apitoa e maua.
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E le gata i leafa'ata'ita'iga fa'atonu fa'ata'ita'i fa'atonu leleie mana'omia e fa'amautu le aoga, saogalemu, tu'u lelei, ma auala fa'atonutonu i tagata.
Taimi meli: Sep-23-2025