Plozasiran

Plozasiran (API)

Talosaga su'esu'e:
O le Plozasiran API o se RNA fa'alavelave laiti (siRNA) fa'atupuina mo le togafitia o le hypertriglyceridemia ma fa'afitauli cardiovascular ma metabolic. E fa'atatau i leAPOC3gene, lea e faʻapipiʻiina apolipoprotein C-III, o se faʻatonuga autu o le metabolism triglyceride. I suʻesuʻega, o loʻo faʻaaogaina Plozasiran e suʻesuʻe ai le RNAi-based lipid-lowering strategy, gene-silencing specificity, ma togafitiga umi mo tulaga e pei ole family chylomicronemia syndrome (FCS) ma fefiloi dyslipidemia.

Galuega:
Plozasiran galue e ala i le fa'aguguAPOC3mRNA i le ate, e taʻitaʻia ai le faʻaitiitia o le maualuga o le apolipoprotein C-III. O lenei mea e faʻaleleia atili ai le lipolysis ma le faʻamamaina o lipoproteins e mauoa i le triglyceride mai le toto. I le avea ai o se API, e mafai ai e Plozasiran le atinaʻeina o togafitiga umi e faʻatatau i le faʻaitiitia o le maualuga o le triglyceride ma faʻaitiitia ai le lamatiaga o le pancreatitis ma le fatu cardiovascular i tagata mamaʻi e iai faʻafitauli ogaoga poʻo le genetic lipid.