Sildenafil Citrate Togafitiga Erectile Dysfunction 171599-83-0
Fa'amatalaga Oloa
| Igoa | Sildenafil Citrate |
| Numera CAS | 171599-83-0 |
| fua mole | C28H38N6O11S |
| mamafa mole | 666.70 |
| EINECS Numera | 200-659-6 |
| Merck | 14,8489 |
| Malosi | 1.445g/cm3 |
| Tulaga teuina | 2-8°C |
| Fomu | O le pauta |
| Lanu | Lanu pa'epa'e |
| Suavai soluble | DMSO: >20mg/mL |
Synonyms
Viagra, Sildenafil citrate; 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl) -4-ethoxyphenyl]sulfonyl]-4-methylpiperazinecitratessalt; 5-[2-Ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo [5,4-e] pyrimidin-7-onecitratessalt; 1-[[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl) -4-ethoxyphenyl]sulfonyl]-4-methylpiperazine,2-hydroxy-1,2,3-propanetricarboxylate; SildenafilCitrate(100mg); Sildenafilcitrate,>=99%;Sildenafilcitrate,Professionalsupply; 5-[2-Ethoxy-5-[(4-methyl-piperazin-1-yl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-onecitrate
Aafiaga ole Pharmacological
Gaioiga Fa'afoma'i
O le Sildenafil citrate o se inhibitor 5-phosphodiesterase filifilia e faʻaleleia ai le nitric oxide-faʻalagolago, cyclic guanosine monophosphate-mediated pulmonary vasodilation e ala i le taofia o le malepelepe o le cyclic guanosine monophosphate. I le faaopoopo atu i le faʻalauteleina saʻo o vaʻa toto pulmonary, e mafai foʻi ona taofia pe toe faʻafoʻisia le toe faʻaleleia o alatoto.
Meatotino Faafomai ma Talosaga
Sildenafil citrate, igoa tau fefaʻatauaʻiga Viagre, e masani ona taʻua o Viagra, o le cyclic guanosine monophosphate (cGMP) -specific phosphodiesterase type 5 (PDE5) inhibitor lea e mafai ona faʻaleleia le fausiaina pe a uma le tautala tautala. Sildenafil citrate e mafai ona faʻaleleia le aʻafiaga o le nitric oxide (NO) e ala i le taofiofia o le ituaiga 5 phosphodiesterase lea e faʻaumatia ai le cyclic guanosine monophosphate (cGMP) i le corpus cavernosum. Faʻateleina le maualuga o le cGMP i le corpus cavernosum, faʻamalo le maso lamolemole i le corpus cavernosum, faʻateleina le tafe toto, faʻaumi le taimi o le faʻatutuina o le penis ma faʻateleina le mausali. Mo tagata mama'i ma'i fa'aletonu le erectile. E ave e tagata matutua le 50 mg i le tautala i taimi taʻitasi, e oʻo atu i le 1 taimi i le aso, ma faʻaaoga pe a manaʻomia pe a ma le 1 itula aʻo leʻi faia feusuaʻiga. Ole maualuga ole aofa'i ole 0.1g i taimi ta'itasi.
In vivo suʻesuʻega
I maile faʻamaʻi, Sildenafil citrate faʻaleleia le gaioiga o le penile erectile i lalo o le faʻaosofia o le nerve pelvic e ala i le fuaina o le mamafa o le intracavernous. O le Sildenafil citrate e matua'i fa'aliliuina le fa'amalieina o le carbamoylcholine-fa'aosofia le fa'amalieina ma fa'alavelaveina le fa'atupuina o le superoxide i totonu o le cavernosal tissue o lapiti hypercholesterolemic. I rats Sprague-Dawley, Sildenafil faʻaleleia le faʻaogaina o le erectile i se taimi-faʻalagolago i le taimi, faʻatasi ai ma le toe faʻaleleia maualuga e tupu i le aso 28 i le fua ole 20 mg / kg i le aso. I isumu Sprague-Dawley, o le pulega o le Sildenafil na mafua ai le faʻasaoina o le maso o le collagen ratio ma le faʻasaoina o le CD31 ma le eNOS faʻaaliga. I rats Sprague-Dawley, Sildenafil faʻaititia tele le faʻamaufaʻailoga apoptotic ma faʻateleina le phosphorylation o akt ma eNOS faʻatusatusa i le vaega faʻatonutonu.
