Atosiban Acetate Fa'aaogaina mo le Fanau Mai Fa'ataoto
Fa'amatalaga Oloa
| Igoa | Atosiban |
| Numera CAS | 90779-69-4 |
| fua mole | C43H67N11O12S2 |
| mamafa mole | 994.19 |
| EINECS Numera | 806-815-5 |
| Fa'apuna | 1469.0±65.0 °C (Va'ai) |
| Malosi | 1.254±0.06 g/cm3(Va'ai) |
| Tulaga teuina | -20°C |
| Solubility | H2O: ≤100 mg/mL |
Fa'amatalaga
Atosiban acetate o se polypeptide cyclic cyclic disulfide e aofia ai 9 amino acids. O se mole o le oxytocin ua suia i tulaga 1, 2, 4 ma le 8. O le N-terminus o le peptide o le 3-mercaptopropionic acid (thiol ma O le sulfhydryl group of [Cys] 6 o loʻo fausia ai se faʻamaufaʻailoga disulfide), o le C-terminal o loʻo i le tulaga o se amide, o le faʻamaʻi modified lona lua i le N-latthy amino acid. [D-Tyr(Et)]2, ma le atosiban acetate o loʻo faʻaaogaina i vailaʻau e pei o le vineka O loʻo i ai i le tulaga o se masima acid, e masani ona taʻua o le atosiban acetate.
Fa'aaogāga
Atosiban o se oxytocin ma vasopressin V1A tu'ufa'atasi tali fa'afeagai, o le oxytocin receptor e tutusa lelei ma le vasopressin V1A fa'afofoga. Pe a poloka le oxytocin receptor, o le oxytocin e mafai lava ona galue e ala i le V1A receptor, o lea e tatau ai ona poloka auala e lua o loʻo i luga i le taimi e tasi, ma o se faʻalavelave e tasi o le tasi tali e mafai ona taofia lelei le faʻamaʻiina o le uterine. O se tasi foi lea o mafuaʻaga autu e le mafai ai e le β-receptor agonists, calcium channel blockers ma le prostaglandin synthase inhibitors ona faʻamalosia lelei le faʻalavelaveina o le uterine.
Aafiaga
Atosiban o se tuʻufaʻatasiga faʻafefe o le oxytocin ma vasopressin V1A, o lona fausaga vailaʻau e tutusa ma le lua, ma e maualuga lona vavalalata mo tali, ma tauva ma oxytocin ma vasopressin V1A faʻafeiloaʻi, ma taofia ai le auala o gaioiga o le oxytocin ma vasopressin ma faʻaitiitia ai faʻalavelave faʻalavelave.
