Leuprorelin Acetate faʻatonutonuina le faʻaogaina o Hormones Gonadal
Fa'amatalaga Oloa
| Igoa | Leuprorelin |
| Numera CAS | 53714-56-0 |
| fua mole | C59H84N16O12 |
| mamafa mole | 1209.4 |
| EINECS Numera | 633-395-9 |
| Ta'amilosaga fa'apitoa | D25 -31.7° (c = 1 i le 1% acetic acid) |
| Malosi | 1.44±0.1 g/cm3(Va'ai) |
| Tulaga teuina | -15°C |
| Fomu | Lelei |
| Acidity coefficient | (pKa) 9.82±0.15 (Vailoaina) |
| Suavai soluble | Solu i le vai ile 1mg/ml |
Synonyms
LH-RHLEUPROLIDE;LEUPROLIDE;LEUPROLIDE(TAGATA);LEUPRORELIN;[DES-GLY10,D-LEU6,PRO-NHET9]-LUTEINIZINGHORMONE-RELEASINGHORMONEHUMAN;(DES-GLY10,D-LEU6,PRO-NHETRING(MLUMONETENE-NHETRING) DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINGHORMONE-RELEASING FACTOR;[DES-GLY10,D-LEU6,PRO-NHET9]-LH-RH(TAGATA)
Aafiaga ole Pharmacological
Leuprolide, goserelin, triprelin, ma le nafarelin o nisi ia o vailaʻau e masani ona faʻaaogaina i falemaʻi e aveese ai ovaries mo togafitiga o le kanesa o le susu aʻo leʻi faʻataʻitaʻiina ma le kanesa prostate.(fa'aigoaina o GnRH-a vaila'au), GnRH-a vaila'au e tutusa i le fausaga ma le GnRH ma tauva ma pituitary GnRH receptors.O lona uiga, o le gonadotropin natia e le pituitary e faʻaitiitia, lea e oʻo atu ai i se faʻaititia tele o le hormone feusuaʻi natia e le ovary.
Leuprolide o se gonadotropin-releasing hormone (GnRH) analog, o se peptide e aofia ai 9 amino acids.O lenei oloa e mafai ona taofia lelei le gaioiga o le pituitary-gonadal system, o le tetee atu i enzymes proteolytic ma le vavalalata i le pituitary GnRH e sili atu le malosi nai lo le GnRH, ma o le gaioiga o le faʻalauiloaina o le tuʻuina atu o le luteinizing hormone (LH) e tusa ma le 20 taimi. o GnRH.E iai fo'i le malosi fa'alavelave fa'alavelave ile galuega pituitary-gonad nai lo le GnRH.I le laasaga muamua o togafitiga, o le follicle stimulating hormone (FSH), LH, estrogen poʻo le androgen e mafai ona faʻateleina mo sina taimi, ona faʻaitiitia ai lea o le tali atu o le pituitary gland, o le faʻaogaina o le FSH, LH ma le estrogen poʻo le androgen ua taofia, e mafua ai ona faalagolago i hormones o feusuaiga.O fa'ama'i fa'afeusuaiga (pei o le kanesa prostate, endometriosis, ma isi) e iai sona a'afiaga.
I le taimi nei, o le masima acetate o le leuprolide e masani ona faʻaaogaina ile falemaʻi, ona o le faʻatinoga o le leuprolide acetate e sili atu ona mautu ile vevela ole potu.Suavai e tatau ona lafoai.E mafai ona faʻaaogaina mo le faʻamaʻiina o vailaʻau o le endometriosis ma le fibroids uterine, le ogatotonu o le matua, le kanesa o le susu muamua ma le kanesa prostate, faʻapea foʻi ma le tafe toto o le uterine e faʻasaina pe le aoga mo togafitiga masani o hormone.E mafai foʻi ona faʻaaogaina e fai ma vailaʻau aʻo leʻi tipi le endometrial, lea e mafai ona faʻamaʻi faʻamaʻi le endometrium, faʻaitiitia le edema, ma faʻaitiitia le faigata o le taotoga.
