Linaclotide mo Gastrointestinal Disorders 851199-59-2
Fa'amatalaga Oloa
| Igoa | Linaclotide |
| Numera CAS | 851199-59-2 |
| fua mole | C59H79N15O21S6 |
| mamafa mole | 1526.74 |
Synonyms
Linaclotide;Linaclotide;LinaelotideAcetate;Linaelotide;CY-14;Liclotide;Argpessin;L-Tyrosine,L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl- L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-,cyclic(1→6),(2→10),(5→13)-tris(disulfide)
Fa'amatalaga
Linaclotide, o se fausaga peptide synthetic o loʻo i ai 14 amino acids, e fesoʻotaʻi ma le endogenous guanosine peptide aiga ma e naʻo le pau lea o le FDA-faʻatagaina GC-C (guanylate) Cyclase-C) vailaʻau faʻamaʻi mo le togafitia o le maʻi o le manava ita ma le manava (IBS- C) ma faʻamaʻi faʻamaʻi idiopathic (CIC) i tagata matutua.
Meatotino tau vailaau
Linaclotide ose pa'epa'e pa'epa'e amorphous pauta;solute itiiti i le vai ma vai vaifofo sodium chloride (0.9%).
E faapefea ona galue
Linaclotide o se guanylate cyclase-C receptor agonist (GCCA) faʻatasi ai ma analgesic visceral ma gaioiga endocrine.O le linaclotide ma lona metabolite malosi e mafai ona fusifusia i le guanylate cyclase-C (GC-C) faʻafeiloaʻi i luga o le malamalama o le epithelium o le intestinal laiti.I faʻataʻitaʻiga manu, linaclotide faʻaitiitia le tiga visceral ma faʻateleina le felauaiga o le manava e ala i le faʻagaoioia o le GC-C, ma i totonu o tagata, o le vailaʻau e faʻateleina ai foi le feʻaveaʻi colonic.O le taunuʻuga o le faʻagaioiina o le GC-C ua faʻateleina le intracellular ma extracellular cGMP (cyclic guanosine monophosphate) faʻatonuga.Extracellular cGMP e mafai ona faʻaitiitia le gaioiga o alava neura tiga ma faʻaitiitia le tiga visceral i manu faʻataʻitaʻiga.Intracellular cGMP e mafai ona faʻateleina le faʻaogaina o le chloride ma le bicarbonate i totonu o le tootoo laiti e ala i le faʻagaoioia o le CFTR (cystic fibrosis transmembrane conductance regulator), lea e iu ai ina oʻo atu i le faʻateleina o le sua o le intestinal laiti ma le saoasaoa o le felauaiga o le intestinal laiti.
FAQ
E te fa'amautinoa le saogalemu ma le saogalemu o le tu'uina atu o oloa?
Ioe, matou te fa'aogaina i taimi uma le afifiina o oloa auina atu i fafo.Matou te fa'aogaina fo'i fa'apitoa fa'apipi'iina o mea lamatia mo oloa mata'utia ma fa'amaonia mea e teu ai malulu mo mea ma'ale'ale vevela.Fa'apitoa fa'apipi'i ma mea e mana'omia e teu fa'ata'atia e ono fa'aopoopoina se totogi fa'aopoopo.
Ae fa'afefea le tau o felauaiga?
O le tau o felauaiga e faʻalagolago i le auala e te filifilia e maua ai oloa.Fa'aaliga e masani lava o le auala sili ona vave ae sili ona taugata.O uta i le sami o le fofo sili lea mo tupe tetele.O fua faatatau tonu o uta e mafai ona matou avatu ia te oe pe a matou iloa auiliiliga o le aofaʻi, mamafa ma le auala.Fa'amolemole fa'afeso'ota'i matou mo nisi fa'amatalaga.
