Linaclotide mo Gastrointestinal Disorders 851199-59-2
Fa'amatalaga Oloa
| Igoa | Linaclotide |
| Numera CAS | 851199-59-2 |
| fua mole | C59H79N15O21S6 |
| mamafa mole | 1526.74 |
Synonyms
Linaclotide;Linaclotide;LinaelotideAcetate;Linaelotide;CY-14;Liclotide;Argpessin;L-Tyrosine,L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl -L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-,cyclic(1→6),(2→10),(5→13)-tris(disulfide)
Fa'amatalaga
Linaclotide, o se peptide synthetic structure o loʻo i ai le 14 amino acids, e fesoʻotaʻi ma le endogenous guanosine peptide family ma e naʻo le FDA-faʻatagaina GC-C (guanylate) Cyclase-C) vailaʻau faʻamaʻi mo le togafitiga o le maʻi itaitaʻi ma le manava (IBS-C) ma le faʻamaʻi tumau idiopathic (CIC) faʻamaʻi.
Meatotino tau vailaau
Linaclotide ose pa'epa'e e pa'epa'e amorphous pauta; solu itiiti i le vai ma vai vaifofo sodium chloride (0.9%).
E faapefea ona galue
Linaclotide o le guanylate cyclase-C receptor agonist (GCCA) faʻatasi ai ma analgesic visceral ma gaioiga endocrine. O le linaclotide ma lona metabolite malosi e mafai ona fusifusia i le guanylate cyclase-C (GC-C) faʻafeiloaʻi i luga o le luminal surface o le epithelium intestinal laiti. I faʻataʻitaʻiga manu, linaclotide e faʻaitiitia ai le tiga o le visceral ma faʻateleina le felauaiga o le manava e ala i le faʻagaoioia o le GC-C, ma i totonu o tagata, o le vailaʻau e faʻateleina ai le feʻaveaʻi colonic. O le iʻuga o le faʻagaioiina o le GC-C ua faʻateleina le intracellular ma extracellular cGMP (cyclic guanosine monophosphate) concentrations. Extracellular cGMP e mafai ona faʻaititia le gaioiga o alava neura tiga ma faʻaitiitia le tiga visceral i manu faʻataʻitaʻiga. Intracellular cGMP e mafai ona faʻateleina le faʻaogaina o le chloride ma le bicarbonate i totonu o le tootoo laiti e ala i le faʻagaoioia o le CFTR (cystic fibrosis transmembrane conductance regulator), lea e iu ai ina oʻo atu i le faʻateleina o le sua o le intestinal ma le saoasaoa o le felauaiga o le intestinal laiti.
FAQ
E te fa'amaonia le saogalemu ma le saogalemu o le tu'uina atu o oloa?
Ioe, matou te faʻaaogaina i taimi uma le faʻapipiʻiina o oloa auina atu i fafo. Matou te fa'aogaina fo'i mea fa'apitoa e teu ai lamatiaga mo oloa mata'utia ma fa'amaonia mea e teu ai malulu mo mea e ma'ale'ale le vevela. Fa'apitoa fa'apipi'i ma mea e mana'omia e teu fa'ata'atia e ono fa'aopoopoina se totogi.
Ae fa'afefea le tau o felauaiga?
O le tau o felauaiga e faalagolago i le auala e te filifilia e maua ai oloa. O le Express e masani lava o le auala sili ona vave ae sili ona taugata. O uta i le sami o le fofo sili lea mo tupe tetele. O fua faatatau tonu o uta e mafai ona matou avatu ia te oe pe a matou iloa auiliiliga o le aofaʻi, mamafa ma le auala. Fa'amolemole fa'afeso'ota'i matou mo nisi fa'amatalaga.
